FROM BRAIN TO TESTIS: IMMUNE ESCAPE AND CLONAL SELECTION IN A B CELL LYMPHOMA WITH SELECTIVE OUT-GROWTH IN TWO IMMUNE SANCTUARIESY

From brain to testis: immune escape and clonal selection in a B cell lymphoma with selective out-growth in two immune sanctuariesy

We describe a patient with a primary diffuse large caruso milk thistle B-cell lymphoma of the central nervous system who developed a localized testicular relapse after 8 years.Both tumours lacked HLA-DR expression, the relapse additionally lost HLA class I expression.Immunoglobulin heavy chain gene rearrangements were identical in both lymphomas wi

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